Journal article

A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy

Anastasia Miron, Myriam Lafreniere-Roula, Chun-Po Steve Fan, Katey R Armstrong, Andreea Dragulescu, Tanya Papaz, Cedric Manlhiot, Beth Kaufman, Ryan J Butts, Letizia Gardin, Elizabeth A Stephenson, Taylor S Howard, Pete F Aziz, Seshadri Balaji, Virginie Beausejour Ladouceur, Lee N Benson, Steven D Colan, Justin Godown, Heather T Henderson, Jodie Ingles Show all

Circulation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

BACKGROUND: Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death (SCD) in children and young adults. Our objective was to develop and validate a SCD risk prediction model in pediatric hypertrophic cardiomyopathy to guide SCD prevention strategies. METHODS: In an international multicenter observational cohort study, phenotype-positive patients with isolated hypertrophic cardiomyopathy 70% prediction accuracy and incorporates risk factors that are unique to pediatric hypertrophic cardiomyopathy. An individualized risk prediction model has the potential to improve the application of clinical practice guidelines and shared decision making for implantable cardioverter defibril..

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Grants

Awarded by National Health and Medical Research Council Career Development Fellowship


Awarded by National Health and Medical Research Council Practitioner Fellowship


Funding Acknowledgements

The project was supported through funding from the Ted Rogers Center for Heart Research, and the Heart and Stroke Foundation/Robert M Freedom Chair (to Dr Mital). Dr Ingles was supported by a National Health and Medical Research Council Career Development Fellowship (no. 1162929). Dr Semsarian was supported by an National Health and Medical Research Council Practitioner Fellowship (no. 1154992).