Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity
Lin Y Hung, Pavitha Parathan, Prapaporn Boonma, Qinglong Wu, Yi Wang, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2020
The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regulate the maturation of the enteric nervous system (ENS). Because microbiota-derived signals that modulate ENS development are poorly understood, we examined the physiological impact of the broad spectrum of antibiotic, vancomycin-administered postweaning on colonic motility, neurochemistry of enteric neurons, and neuronal excitability. The functional impact of vancomycin on enteric neurons was investigated by Ca2+ imaging in Wnt1-Cre;R26R-GCaMP3 reporter mice to characterize alterations in the submucosal and the myenteric plexus, which contains the neuronal circui..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by National Institutes of Health
This research was supported by National Health and Medical Research Council of Australia Project Grants APP1099016 to J. P. P. Foong, J. C. Bornstein, and T. C. Savidge, National Institutes of Health Grants P30-DK-56338 to T. C. Savidge, U01-AI-24290 to T. C. Savidge, and R01-AI-10091401 to T. C. Savidge, and the University of Melbourne International Research and Fee Remission Scholarship to L. Y. Hung.