Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study
Rebecca E Amariglio, Rachel F Buckley, Jennifer S Rabin, Kathryn V Papp, Yakeel T Quiroz, Elizabeth C Mormino, Kathryn P Sparks, Keith A Johnson, Dorene M Rentz, Reisa A Sperling
Journal of Alzheimer's Disease | IOS PRESS | Published : 2020
BACKGROUND: Black Americans are approximately twice as likely to develop dementia as compared to White Americans and the magnitude of this disparity is often attributed to a variety of factors that include psychosocial and vascular risk factors. However, less is known about the potential contribution of Alzheimer's disease pathological differences. OBJECTIVE: To examine potential differences incross-sectional and longitudinal cognitive performance in black and white participants who were clinically normal at baseline. METHODS: 296 participants (48 African-American/black participants) underwent MRI and amyloid PET at baseline. Linear mixed models were used to examine the main effects of race,..View full abstract
Awarded by NIA
Awarded by NIH OD
This work is supported by NIA grant: NIA K23 AG044431 (REA), NIA P01AG036694 (KAJ and RAS), NIA R01AG027435 (RAS and KAJ), and NIA R01AG037497 (KAJ). JSR is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research. YTQ is supported by NIH OD (DP5OD019833) and NIA (R01 AG054671).