Journal article

Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study

Rebecca E Amariglio, Rachel F Buckley, Jennifer S Rabin, Kathryn V Papp, Yakeel T Quiroz, Elizabeth C Mormino, Kathryn P Sparks, Keith A Johnson, Dorene M Rentz, Reisa A Sperling

Journal of Alzheimer's Disease | IOS PRESS | Published : 2020

Abstract

BACKGROUND: Black Americans are approximately twice as likely to develop dementia as compared to White Americans and the magnitude of this disparity is often attributed to a variety of factors that include psychosocial and vascular risk factors. However, less is known about the potential contribution of Alzheimer's disease pathological differences. OBJECTIVE: To examine potential differences incross-sectional and longitudinal cognitive performance in black and white participants who were clinically normal at baseline. METHODS: 296 participants (48 African-American/black participants) underwent MRI and amyloid PET at baseline. Linear mixed models were used to examine the main effects of race,..

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Grants

Awarded by NIA


Awarded by NIH OD


Funding Acknowledgements

This work is supported by NIA grant: NIA K23 AG044431 (REA), NIA P01AG036694 (KAJ and RAS), NIA R01AG027435 (RAS and KAJ), and NIA R01AG037497 (KAJ). JSR is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research. YTQ is supported by NIH OD (DP5OD019833) and NIA (R01 AG054671).