Journal article

Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders

Andre F Carvalho, Marco Solmi, Marcos Sanches, Myrela O Machado, Brendon Stubbs, Olesya Ajnakina, Chelsea Sherman, Yue Ran Sun, Celina S Liu, Andre R Brunoni, Giorgio Pigato, Brisa S Fernandes, Beatrice Bortolato, Muhammad Husain, Elena Dragioti, Joseph Firth, Theodore D Cosco, Michael Maes, Michael Berk, Krista L Lanctot Show all

Translational Psychiatry | NATURE PUBLISHING GROUP | Published : 2020

Abstract

The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with conflicting results. An umbrella review of meta-analyses of non-genetic peripheral biomarkers for Alzheimer's disease, autism spectrum disorder, bipolar disorder (BD), major depressive disorder, and schizophrenia, including first-episode psychosis. We included meta-analyses that compared alterations in peripheral biomarkers between participants with mental disorders to controls (i.e., between-group meta-analyses) and that assessed biomarkers after treatment (i.e., within-group meta-analyses). Evidence for association was hierarchically graded using a priori defined criteria against several biases. T..

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University of Melbourne Researchers

Grants

Awarded by National Institute for Health Research (NIHR)


Awarded by National Council for Scientific and Technological Development


Awarded by NHMRC


Awarded by Alzheimer's Association


Awarded by National Institutes of Health


Awarded by Canadian Institutes for Health Research


Awarded by Alzheimer's Drug Discovery Foundation


Awarded by Alzheimer Society of Canada


Awarded by National Institute of Mental Health


Awarded by Brain & Behavior Research Foundation


Funding Acknowledgements

Olesya Ajnakina is funded by the National Institute for Health Research (NIHR) (NIHR Post-Doctoral Fellowship-PDF-2018-11-ST2-020). The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care. A.R.B. is supported by productivity grants from the National Council for Scientific and Technological Development (CNPQ-1B) and the Program of Academic Productivity (PIPA) of the University of SAo Paulo Medical School. M.I.H. has received grants from the Pakistan Institute of Living and Learning (PILL), the Physician's Services Incorporated (PSI) Foundation and the Stanley Medical Research Institute (SMRI). J.F. is supported by a Blackmores Institute Fellowship. M.B. has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, Medical Benefits Fund, National Health and Medical Research Council, Medical Research Futures Fund, Beyond Blue, Rotary Health, A2 milk company, Meat and Livestock Board, Woolworths, Avant and the Harry Windsor Foundation. M.B. is supported by a NHMRC Senior Principal Research Fellowship 1059660 and 1156072. K.L.L. has grants from the Alzheimer's Association (PTC-18-543823), National Institutes of Health (R01AG046543), Canadian Institutes for Health Research (MOP 201803PJ8), Alzheimer's Drug Discovery Foundation (grant #1012358) Alzheimer Society of Canada (Grant 15-17). E.V. has received grants from the Brain and Behaviour Foundation, the Generalitat de Catalunya (PERIS), the Spanish Ministry of Science, Innovation and Universities (CIBERSAM), EU Horizon 2020, and the Stanley Medical Research Institute. D.A.P. was partially supported by R37MH068376 from the National Institute of Mental Health and a NARSAD Distinguished Investigator Award, Brain & Behavior Research Foundation (grant #26950). N.H. has received research support from the Canadian Institute of Health Research, National Institute on Aging, Alzheimer Society of Canada, Alzheimer's Association US, and Alzheimer's Drug Discovery Foundation.