MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection
Amy L Ellis, Alexis J Balgeman, Erica C Larson, Mark A Rodgers, Cassaundra Ameel, Tonilynn Baranowski, Nadean Kannal, Pauline Maiello, Jennifer A Juno, Charles A Scanga, Shelby L O'Connor
PLOS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2020
Mucosal-associated invariant T (MAIT) cells can recognize and respond to some bacterially infected cells. Several in vitro and in vivo models of Mycobacterium tuberculosis (Mtb) infection suggest that MAIT cells can contribute to control of Mtb, but these studies are often cross-sectional and use peripheral blood cells. Whether MAIT cells are recruited to Mtb-affected granulomas and lymph nodes (LNs) during early Mtb infection and what purpose they might serve there is less well understood. Furthermore, whether HIV/SIV infection impairs MAIT cell frequency or function at the sites of Mtb replication has not been determined. Using Mauritian cynomolgus macaques (MCM), we phenotyped MAIT cells ..View full abstract
Awarded by National Institutes of Health (NIH)
Shelby L. O'Connor (SLO) received the following funding from the National Institutes of Health (NIH): R21 AI127127 (URL: www.nih.gov).Charles A. Scanga (CAS) received the following funding from the National Institutes of Health (NIH): NIH RO1 AI-111815 (URL: www.nih.gov).The sponsors/funders did not play any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.