Journal article

Immunogenic profile of SARS-CoV-2 spike in individuals recovered from COVID-19

Jennifer Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah Kelly, Kathleen Wragg, Robyn Esterbauer, Helen Kent, Jane Batten, Francesca Mordant, Nicholas Gherardin, Phillip Pymm, Melanie Dietrich, Nichollas Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles Davenport, Stephen Kent, Adam Wheatley

Cold Spring Harbor Laboratory | Published : 2020

Abstract

The rapid global spread of SARS-CoV-2 and resultant mortality and social disruption have highlighted the need to better understand coronavirus immunity to expedite vaccine development efforts. Multiple candidate vaccines, designed to elicit protective neutralising antibodies targeting the viral spike glycoprotein, are rapidly advancing to clinical trial. However, the immunogenic properties of the spike protein in humans are unresolved. To address this, we undertook an in-depth characterisation of humoral and cellular immunity against SARS-CoV-2 spike in humans following mild to moderate SARS-CoV-2 infection. We find serological antibody responses against spike are routinely elicited by infec..

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