Journal article

A single point mutation in the Plasmodium falciparum ftsh1 metalloprotease confers actinonin resistance

Christopher D Goodman, Taher Uddin, Natalie J Spillman, Geoffrey I McFadden

Cold Spring Harbor Laboratory


AbstractThe antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity against bacteria. However, Amberg Johnson et al. (2017) identified the metalloprotease TgFtsH1 as the target of actinonin in the related parasite Toxoplasma gondii and implicated actinonin in the inhibition of P. falciparum growth. The authors were not, however, able to recover actinonin resistant malaria parasites, leaving the specific target of actinonin uncertain. We generated actinonin resistant P. falciparum by in vitro selection..

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University of Melbourne Researchers

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