Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study

Sara Larivière; Raúl Rodríguez-Cruces; Jessica Royer; Maria Eugenia Caligiuri; Antonio Gambardella; Luis Concha; Simon S Keller; Fernando Cendes; Clarissa Yasuda; Leonardo Bonilha; Ezequiel Gleichgerrcht; Niels K Focke; Martin Domin; Felix von Podewills; Soenke Langner; Christian Rummel; Roland Wiest; Pascal Martin; Raviteja Kotikalapudi; Terence J O’Brien; Benjamin Sinclair; Lucy Vivash; Patricia M Desmond; Saud Alhusaini; Colin P Doherty; Gianpiero L Cavalleri; Norman Delanty; Reetta Kälviäinen; Graeme D Jackson; Magdalena Kowalczyk; Mario Mascalchi; Mira Semmelroch; Rhys H Thomas; Hamid Soltanian-Zadeh; Esmaeil Davoodi-Bojd; Junsong Zhang; Matteo Lenge; Renzo Guerrini; Emanuele Bartolini; Khalid Hamandi; Sonya Foley; Bernd Weber; Chantal Depondt; Julie Absil; Sarah JA Carr; Eugenio Abela; Mark P Richardson; Orrin Devinsky; Mariasavina Severino; Pasquale Striano; Domenico Tortora; Sean N Hatton; Sjoerd B Vos; John S Duncan; Christopher D Whelan; Paul M Thompson; Sanjay M Sisodiya; Andrea Bernasconi; Angelo Labate; Carrie R McDonald; Neda Bernasconi; Boris C Bernhardt

Journal article

Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study

Sara Larivière, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K Focke, Martin Domin, Felix von Podewills, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Terence J O’Brien Show all

Cold Spring Harbor Laboratory | Published : 2020

DOI: 10.1101/2020.05.04.076836

Abstract

SUMMARYEpilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1,021 adults with epilepsy compared to 1,564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy co-localized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortic..

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