Journal article

Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old

Tengyi Cai, Vasiliki Karlaftis, Stephen Hearps, Susan Matthews, Janet Burgess, Paul Monagle, Vera Ignjatovic

Pediatric Nephrology | SPRINGER | Published : 2020


BACKGROUND: Serum cystatin C (CysC) is a promising biomarker of kidney function, which has higher accuracy and sensitivity when compared with creatinine. To better utilize serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC. METHODS: The study subjects consisted of healthy term neonates and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunoturbidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs. RESULTS: A total of 378 samples with equal ..

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Funding Acknowledgements

This study was funded by the Royal Children's Hospital Foundation, with supplementary funding from Ortho Clinical Diagnostics and in-kind reagents supplied from the Medical and Scientific Affairs at Roche Diagnostics International during the study.