Journal article

Harm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review

Fumitaka Yanase, Tomoko Fujii, Thummaporn Naorungroj, Alessandro Belletti, Nora Luethi, Anitra C Carr, Paul J Young, Rinaldo Bellomo

Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020


OBJECTIVES: The potential harm associated with the use of IV vitamin C has not been systematically assessed. We aimed to review the available evidence on harm related to such treatment. DATA SOURCES: We searched MEDLINE, EMBASE, Cochrane Library, National Institute of Health Clinical Trials Register, and World Health Organization International Clinical Trials Registry Platform. STUDY SELECTION: We included studies in adult population that reported harm related to IV high-dose vitamin C which we defined as greater than or equal to 6 g/d, greater than or equal to 75 mg/kg/d, or greater than or equal to 3 g/m/d. DATA EXTRACTION: Two independent investigators screened records and extracted data...

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University of Melbourne Researchers


Funding Acknowledgements

Dr. Yanase received scholarship for PhD course in Monash University from Japan Student Services Organization and Endeavour scholarship. And this research was completed during the tenure of a Health Research Council of New Zealand Clinical Practitioner Fellowship held by Dr. Young. Dr. Carr disclosed that she is a Health Research Council of New Zealand Sir Charles Hercus Health Research Fellowship. The remaining authors have disclosed that they do not have any potential conflicts of interest.