Journal article
Harm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review
Fumitaka Yanase, Tomoko Fujii, Thummaporn Naorungroj, Alessandro Belletti, Nora Luethi, Anitra C Carr, Paul J Young, Rinaldo Bellomo
Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
Abstract
OBJECTIVES: The potential harm associated with the use of IV vitamin C has not been systematically assessed. We aimed to review the available evidence on harm related to such treatment. DATA SOURCES: We searched MEDLINE, EMBASE, Cochrane Library, National Institute of Health Clinical Trials Register, and World Health Organization International Clinical Trials Registry Platform. STUDY SELECTION: We included studies in adult population that reported harm related to IV high-dose vitamin C which we defined as greater than or equal to 6 g/d, greater than or equal to 75 mg/kg/d, or greater than or equal to 3 g/m/d. DATA EXTRACTION: Two independent investigators screened records and extracted data...
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Funding Acknowledgements
Dr. Yanase received scholarship for PhD course in Monash University from Japan Student Services Organization and Endeavour scholarship. And this research was completed during the tenure of a Health Research Council of New Zealand Clinical Practitioner Fellowship held by Dr. Young. Dr. Carr disclosed that she is a Health Research Council of New Zealand Sir Charles Hercus Health Research Fellowship. The remaining authors have disclosed that they do not have any potential conflicts of interest.