Journal article
Continuous renal replacement therapy and its impact on hyperammonaemia in acute liver failure
S Warrillow, C Fisher, H Tibballs, M Bailey, C McArthur, P Lawson-Smith, B Prasad, M Anstey, B Venkatesh, G Dashwood, J Walsham, A Holt, U Wiersema, D Gattas, M Zoeller, MG Álvarez, R Bellomo
Critical Care and Resuscitation | AUSTRALASIAN MED PUBL CO LTD | Published : 2020
DOI: 10.51893/2020.2.oa6
Open access
Abstract
Objective: Hyperammonaemia contributes to complications in acute liver failure (ALF) and may be treated with continuous renal replacement therapy (CRRT), but current practice is poorly understood. Design: We retrospectively analysed data for baseline characteristics, ammonia concentration, CRRT use, and outcomes in a cohort of Australian and New Zealand patients with ALF. Setting: All liver transplant ICUs across Australia and New Zealand. Participants: Sixty-two patients with ALF. Main outcome measures: Impact of CRRT on hyperammonaemia and patient outcomes. Results: We studied 62 patients with ALF. The median initial (first 24 h) peak ammonia was 132 mmol/L (interquartile range [IQR], 91–1..
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