Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts.
Alba Cortés, John Wills, Xiaopei Su, Rachel E Hewitt, Jack Robertson, Riccardo Scotti, Daniel RG Price, Yvonne Bartley, Tom N McNeilly, Lutz Krause, Jonathan J Powell, Alasdair J Nisbet, Cinzia Cantacessi
Microbiome | Published : 2020
BACKGROUND: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships. In spite of the plethora of data available on the impact that GI helminths exert on the composition of the gut microflora, whether alterations of microbial profiles are caused by direct parasite-bacteria interactions or, indirectly, by alterations of the GI environment (e.g. mucosal immunity) remains to be determined. Furthermore, no data is thus far available on the downstream roles that qualitative and quantitative changes in gut microbial composition play in the overall path..View full abstract
Awarded by Medical Research Council