Journal article

Long-term effect of YAG laser iridotomy on corneal endothelium in primary angle closure suspects: a 72-month randomised controlled study

Chimei Liao, Jian Zhang, Yuzhen Jiang, Shengsong Huang, Tin Aung, Paul J Foster, David Friedman, Mingguang He

BRITISH JOURNAL OF OPHTHALMOLOGY | BMJ PUBLISHING GROUP | Published : 2021

Abstract

PURPOSES: To evaluate the effect of YAG laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) and morphology in primary angle closure suspects (PACS) over 72 months. METHODS: The Zhongshan Angle Closure Prevention Trial is a single-centre randomised controlled trial. Subjects with bilateral PACS received YAG LPI prophylactic treatment in one eye randomly, while the fellow eye served as control. Central corneal ECD and morphology were assessed using non-contact specular microscopy (SP-2000P, Topcon) at baseline, 6, 18, 36, 54 and 72 months postoperatively. Mixed model analysis was conducted to compare the difference between treated and fellow eyes. RESULTS: A total of 875..

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University of Melbourne Researchers

Grants

Awarded by Fight for Sight (UK)


Awarded by Sun Yat-sen University 5010 Project Fund (China)


Awarded by National Natural Science Foundation of China (China)


Awarded by National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital, London, UK


Funding Acknowledgements

This work is supported by the Fight for Sight (grant no. 1655) (UK), the Sun Yat--sen University 5010 Project Fund (grant no. 2007033) (China), the National Natural Science Foundation of China (grant no. 81420108008) (China), Special Trustees of Moorfields Eye Hospital (via Fight for Sight), Johns Hopkins University and Fundamental Research Funds of the State Key Laboratory in Ophthalmology (China). Professor MH receives support from the University of Melbourne Research at Melbourne Accelerator Program Professorship. The Centre for Eye Research Australia receives operational infrastructural support from the Victorian government. Dr YJ and Professor PJF supported by a grant from the British Council for Prevention of Blindness (UK). Professor PJF received additional support from the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital, London, UK (NIHR-BRC2 009; Moorfields/UCL-IOO), Special Trustees of Moorfields Eye Hospital (since renamed Moorfields Eye Charity) and the Richard Desmond Charitable Foundation (via Fight for Sight UK).