Journal article

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study

Maytham Hussein, John A Karas, Elena K Schneider-Futschik, Fan Chen, James Swarbrick, Olivia KA Paulin, Daniel Hoyer, Mark Baker, Yan Zhu, Jian Li, Tony Velkov

mSystems | American Society for Microbiology | Published : 2020

Abstract

Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from a hitherto-unculturable soil bacterium, Eleftheria terrae, and recognized as a potent antibacterial agent against various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. The most distinctive characteristic of teixobactin as an effective antibiotic is that teixobactin resistance could not be evolved in a laboratory setting. It is purported that teixobactin’s “resistance-resistant” m..

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