Journal article

Pan-transcriptomic analysis identified common differentially expressed genes of Acinetobacter baumannii in response to polymyxin treatments

Mengyao Li, Su Mon Aye, Maizbha Uddin Ahmed, Mei-Ling Han, Chen Li, Jiangning Song, John Boyce, David Powell, Mohammad AK Azad, Tony Velkov, Yan Zhu, Jian Li

Molecular Omics | Royal Society of Chemistry (RSC) | Published : 2020

Abstract

Multidrug-resistant Acinetobacter baumannii is a top-priority Gram-negative pathogen and polymyxins are a last-line therapeutic option. Previous systems pharmacological studies examining polymyxin killing and resistance usually focused on individual strains, and the derived knowledge could be limited by strain-specific genomic context. In this study, we examined the gene expression of five A. baumannii strains (34654, 1207552, 1428368, 1457504 and ATCC 19606) to determine the common differentially expressed genes in response to polymyxin treatments. A pan-genome containing 6061 genes was identified for 89 A. baumannii genomes from RefSeq database which included the five strains examined in t..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health


Funding Acknowledgements

The authors thank Professor David A. Rasko at the University of Maryland for sharing transcriptomic data via GEO database. J. L. and T. V. were supported by National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01 AI132154). J. L. is an Australian National Health and Medical Research Council (NHMRC) Principal Research Fellow and T. V. is an NHMRC Career Development Level 2 Fellow. C. L. is an NHMRC CJ Martin Early Career Research Fellow. The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health.