Do Levels of Stress Markers Influence the Retinal Nerve Fiber Layer Thickness in Young Adults?
Samantha Sze-Yee Lee, Paul G Sanfilippo, Seyhan Yazar, Craig E Pennell, Alex W Hewitt, Carol A Wang, Wrivu N Martin, David A Mackey
JOURNAL OF GLAUCOMA | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
PRECIS: Although mental or emotional stress may result raise in intraocular pressure (IOP) we found weak associations between endogenous stress markers concentrations and retinal nerve fiber layer (RNFL) thickness, thus limited evidence that stress affects retinal ganglion cells integrity. PURPOSE: Increased exposure to glucocorticoids is linked to elevated IOP, which is a risk factor for glaucoma. We explored the RNFL thickness for changes that may mimic preclinical glaucomatous changes, in relation to the hormonal stress response. MATERIALS AND METHODS: Young healthy adults (n=863) underwent a Trier Social Stress Test. Endogenous plasma adrenocorticotropic hormone (ACTH) and cortisol were ..View full abstract
P.G.S. and S.Y. are supported by NHMRC Early Career Fellowships. A.W.H. is supported by a NHMRC Practitioner Fellowship.