Journal article

Proteomic identification of Coxiella burnetii effector proteins targeted to the host cell mitochondria during infection

Laura Fielden, Nichollas Scott, Catherine Palmer, Chen Ai Khoo, Hayley Newton, Diana Stojanovski

Published : 2020


Modulation of the host cell is integral to the survival and replication of microbial pathogens. Several intracellular bacterial pathogens deliver a cohort of bacterial proteins, termed ‘effector proteins’ into the host cell during infection by sophisticated protein translocation systems which manipulate cellular processes and functions. Despite the importance of these proteins during infection the functional contribution of individual effectors is poorly characterised, particularly in intracellular bacterial pathogens with large effector protein repertoires. Technical caveats have limited the capacity to study these proteins during a native infection, with many effector proteins having only ..

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