Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group

Grants

Funding Acknowledgements

The ENIGMA-Major Depressive Disorder working group gratefully acknowledges support from the NIH Big Data to Knowledge (BD2K) award (U54 EB020403 to PT). LS is supported by a NHMRC Career Development Fellowship (1140764). PT is supported by grant R01MH116147. NJ is supported by grant R01MH117601. Muenster Cohort: The Muenster Neuroimaging Cohort was supported by grants of the German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to UD; SFBTRR58, Projects C09 and Z02 to UD;) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant Dan3/012/17 to UD and SEED 11/18 to NO) and the Deanery of the Medical Faculty of the University of Munster. These funders had no role in designing the study; collection, management, analysis, and interpretation of data; writing of the report; nor the decision to submit the report for publication. FOR2107: The FOR2107 consortium is supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, Grant nos. KI 588/14-1, KI 588/14-2, KR 3822/7-1, KR 3822/7-2, NE 2254/1-2, DA1151/5-1, DA1151/5-2, SCHW 559/14-1, 545/7-2, RI 908/11-2, WI 3439/3-2, NO 246/10-2, DE 1614/3-2, HA 7070/2-2, JA 1890/7-1, JA 1890/7-2, MU 1315/8-2, RE 737/20-2, KI 588/17-1). TH was supported by the German Research Foundation (DFG grants HA7070/2-2, HA7070/3, HA7070/4) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (MzH3/020/20). BiDirect: The BiDirect-Study is funded by the German Federal Ministry of Education and Research (grants 01ER0816, 01ER1506 and 01ER1205). NESDA: Funding was obtained from the Netherlands Organization for Scientific Research (Geestkracht program grant 10-000-1002); the Center for Medical Systems Biology (CSMB, NWO Genomics), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL), VU University's Institutes for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam, University Medical Center Groningen, Leiden University Medical Center, National Institutes of Health (NIH, R01D0042157-01A, MH081802, Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995). Part of the genotyping and analyses were funded by the Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health.Computing was supported by BiG Grid, the Dutch e-Science Grid, which is financially supported by NWO. LS is supported by a NHMRC Career Development Fellowship (1140764) and grant R01MH117601. Bipolar Family Study: The Bipolar Family Study received funding from the European Union's Seventh Framework Programme for research under grant agreement n degrees 602450. This study is also supported by Wellcome Trust award 104036/Z/14/Z. CODE: The CODE cohort was collected from studies funded by Lundbeck and the German Research Foundation (WA 1539/4-1, SCHN 1204/3-1). MPIP: The MPIP Munich Morphometry Sample comprises patients included in Munich Antidepressant Response Signature study and the Recurrent Unipolar Depression (RUD) Case-Control study, and control subjects acquired at the Ludwig-Maximilians-University, Munich, Department of Psychiatry. We wish to acknowledge Rosa Schirmer, Elke Schreiter, Reinhold Borschke, and Ines Eidner for MR image acquisition and data preparation, and Benno Putz, and Bertram Muller-Myhsok for distributed computing support and the MARS and RUD Study teams for clinical phenotyping. We thank Dorothee P. Auer for initiation of the RUD study. The MARS study is supported by a grant of the ExzellenzStiftung of the Max Planck Society.This work has also been funded by the Federal Ministry of Education and Research (BMBF) in the framework of the National Genome Research Network (NGFN), FKZ 01GS0481. SHIP: SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. This study was further supported by the EU-JPND Funding for BRIDGET (FKZ:01ED1615). Stanford: NIMH Grant R37-101495 to IG, and the National Science Foundation Integrative Graduate Education and Research Traineeship (NSF IGERT) Recipient Award 0801700 and National Science Foundation Graduate Research Fellowship Program (NSF GRFP) DGE-1147470 to MS. Melbourne: The study was funded by National Health and Medical Research Council of Australia (NHMRC) Project Grants 1064643 (PI BH) and 1024570 (PI CD). Houston: Supported in part by NIMH grant R01 085667, The Dunn Foundation, and the Pat Rutherford, Jr. Endowed Chair in Psychiatry to JCS. Imaging genetics Dublin and Clinical Depression Dublin: The study was supported by a Science Foundation Ireland (SFI) Stokes Professorship Grant to Thomas Frodl. Novosibirsk: Russian Science Foundation grant #16-15-00128 to Lyubomir Aftanas. Sydney: This study was supported by the following National Health & Medical Research Council funding sources: Program Grant (No. 566529), Centres of Clinical Research Excellence Grant (No. 264611), Australia Fellowship (No. 464914) and Clinical Research Fellowship (No. 402864). Calgary: The study was supported by Branch Out Neurological Foundation, Alberta Children's Hospital Foundation. Magdeburg: The study was funded through the SFB779. Minnesota: The study was supported by K23MH090421, P41RR008079, National Alliance for Research on Schizophrenia and Affective Disorders, University of Minnesota Graduate School, Minnesota Medical Foundation, Deborah E. Powell Center for Women's Health Seed Grant. Singapore: The study was supported by grant NHG SIG/15012.