Journal article

Cross-sectional metabolic profiles of mental health in population-based cohorts of 11-to 12-year-olds and mid-life adults: The Longitudinal Study of Australian Children

Katherine Lange, Kate Lycett, Susan Ellul, Richard Saffery, Fiona Mensah, John Carlin, Lisa Gold, Edwards Ben, Peter Azzopardi, Michael Sawyer, Markus Juonala, David Burgner, Melissa Wake

Australian & New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2020

Abstract

Objective: Poorer mental health in adulthood is associated with increased risk of cardiovascular disease and reduced life expectancy. However, little is known of the molecular pathways underpinning this relationship and how early in life adverse metabolite profiles relate to self-reported variation in mental health. We examined cross-sectional associations between mental health and serum metabolites indicative of cardiovascular health, in large Australian population-based cohorts at two stages of the life-course. Methods: We characterised cross-sectional serum nuclear magnetic resonance metabolite profiles of positively and negatively framed mental health in a large population-based sample o..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (1041352, 1109355); the Royal Children's Hospital Foundation (2014-241); the Murdoch Children's Research Institute; The University of Melbourne, the National Heart Foundation of Australia (100660); Financial Markets Foundation for Children (2014-055, 2016-310); and the Victoria Deaf Education Institute. The following were supported by NHMRC: Senior Research Fellowships MW (1046518) and DPB (1064629); Principal Research Fellowship MW (1160906); Career Development Fellowship FKM (1111160); Early Career Fellowships KLy (1091124) and LG (1035100). The following were supported by the National Heart Foundation of Australia: Honorary Future Leader Fellowship DPB (100369); Postdoctoral Fellowship KLy (101239). The following was supported by the Royal Children's Hospital Foundation: Postdoctoral Fellowship KLa (2018-984).