Journal article

mCSM-membrane: predicting the effects of mutations on transmembrane proteins.

Douglas EV Pires, Carlos HM Rodrigues, David B Ascher

Nucleic Acids Research | Oxford University Press | Published : 2020

Abstract

Significant efforts have been invested into understanding and predicting the molecular consequences of mutations in protein coding regions, however nearly all approaches have been developed using globular, soluble proteins. These methods have been shown to poorly translate to studying the effects of mutations in membrane proteins. To fill this gap, here we report, mCSM-membrane, a user-friendly web server that can be used to analyse the impacts of mutations on membrane protein stability and the likelihood of them being disease associated. mCSM-membrane derives from our well-established mutation modelling approach that uses graph-based signatures to model protein geometry and physicochemical ..

View full abstract

Grants

Awarded by Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)


Awarded by Jack Brockhoff Foundation [JBF]


Awarded by Wellcome Trust


Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

D.B.A. and D.E.V.P. were funded by a Newton Fund RCUK-CONFAP Grant awarded by the Medical Research Council (MRC) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) [MR/M026302/1]; Jack Brockhoff Foundation [JBF 4186, 2016]; Wellcome Trust [200814/Z/16/Z]; Investigator Grant from the National Health and Medical Research Council (NHMRC) of Australia [GNT1174405]; Victorian Government's OIS Program (in part). Funding for open access charge: MRC.