Comparative Effectiveness of Carotid Endarterectomy vs Initial Medical Therapy in Patients With Asymptomatic Carotid Stenosis
Salomeh Keyhani, Eric M Cheng, Katherine J Hoggatt, Peter C Austin, Erin Madden, Paul L Hebert, Ethan A Halm, Ayman Naseri, Jason M Johanning, Danielle Mowery, Wendy W Chapman, Dawn M Bravata
JAMA Neurology | AMER MEDICAL ASSOC | Published : 2020
Importance: Carotid endarterectomy (CEA) among asymptomatic patients involves a trade-off between a higher short-term perioperative risk in exchange for a lower long-term risk of stroke. The clinical benefit observed in randomized clinical trials (RCTs) may not extend to real-world practice. Objective: To examine whether early intervention (CEA) was superior to initial medical therapy in real-world practice in preventing fatal and nonfatal strokes among patients with asymptomatic carotid stenosis. Design, Setting, and Participants: This comparative effectiveness study was conducted from August 28, 2018, to March 2, 2020, using the Corporate Data Warehouse, Suicide Data Repository, and other ..View full abstract
Awarded by NIH
This study was funded by grant RO1 HL114563-01A1 from the NIH (Dr Keyhani).