Journal article
The Potent Antioxidant MitoQ Protects against Preeclampsia during Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy
Y Yang, P Xu, F Zhu, J Liao, Y Wu, M Hu, H Fu, J Qiao, L Lin, B Huang, H Jin, X Liu, Y Zheng, L Wen, R Saffery, MD Kilby, J Yan, LC Kenny, H Qi, C Tong Show all
Antioxidants and Redox Signaling | MARY ANN LIEBERT, INC | Published : 2021
Abstract
Aims: Although preeclampsia (PE) has been attributed to excessive oxidative stress (OS) in the placenta, mild antioxidants failed to prevent PE in clinical trials. As mitochondria are a major source of OS, this study assessed the potential of a potent mitochondria-targeting antioxidant MitoQ in the prevention of PE. Results: Placentas from women with PE and from reduced uterine perfusion pressure (RUPP) mice demonstrated significantly higher OS, along with increased mitochondrial damage and compromised glutathione peroxidase (GPx) activities. MitoQ administration during late gestation alleviated RUPP-induced PE; whereas early-pregnancy MitoQ treatment not only exacerbated blood pressure, fet..
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Awarded by Chongqing Science and Technology Commission
Funding Acknowledgements
The authors would like to acknowledge support from the "111 program'' of the Ministry of Education P.R.C. and State Administration of Foreign Experts Affairs P.R.C.