The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy
Yike Yang, Ping Xu, Fangyu Zhu, Jiujiang Liao, Yue Wu, Mingyu Hu, Huijia Fu, Juan Qiao, Li Lin, Biao Huang, Huili Jin, Xiyao Liu, Yangxi Zheng, Li Wen, Richard Saffery, Mark D Kilby, Jianying Yan, Louise C Kenny, Hongbo Qi, Chao Tong Show all
ANTIOXIDANTS & REDOX SIGNALING | MARY ANN LIEBERT, INC | Published : 2020
Aims: Although preeclampsia (PE) has been attributed to excessive oxidative stress (OS) in the placenta, mild antioxidants failed to prevent PE in clinical trials. As mitochondria are a major source of OS, this study assessed the potential of a potent mitochondria-targeting antioxidant MitoQ in the prevention of PE. Results: Placentas from women with PE and from reduced uterine perfusion pressure (RUPP) mice demonstrated significantly higher OS, along with increased mitochondrial damage and compromised glutathione peroxidase (GPx) activities. MitoQ administration during late gestation alleviated RUPP-induced PE; whereas early-pregnancy MitoQ treatment not only exacerbated blood pressure, fet..View full abstract
The authors would like to acknowledge support from the "111 program'' of the Ministry of Education P.R.C. and State Administration of Foreign Experts Affairs P.R.C.