Journal article

Associations of retinal microvascular caliber with large arterial function and structure: A population-based study of 11 to 12 year-olds and midlife adults

Mengjiao Liu, Kate Lycett, Tien Yin Wong, Anneke Grobler, Markus Juonala, Mingguang He, Terry Dwyer, David Burgner, Melissa Wake

MICROCIRCULATION | WILEY | Published : 2020

Abstract

OBJECTIVE: We examined associations between retinal microvascular and large arterial phenotypes to explore relationships between the micro- and macro-vasculature in childhood and midlife. METHODS: Participants were 1288 children (11-12 years, 50.9% female) and 1264 adults (mean age 44 years, 87.6% female) in a cross-sectional population-based study. Exposures were retinal arteriolar and venular caliber quantified from retinal images. Outcomes included arterial function (pulse wave velocity; carotid arterial elasticity) and structure (carotid intima-media thickness). Multivariable regression models were performed adjusting for age, sex, and family socioeconomic position. RESULTS: In children,..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by Australian National Health & Medical Research Council (NHMRC) Early Career Fellowship


Awarded by National Heart Foundation


Awarded by NHMRC


Funding Acknowledgements

This work has been supported to date by the National Health and Medical Research Council of Australia (NHMRC; 1041352, 1109355), The Royal Children's Hospital Foundation (2014-241), Murdoch Children's Research Institute, The University of Melbourne, National Heart Foundation of Australia (100660) and Financial Markets Foundation for Children (2014-055; 2016-310). ML is supported by a Melbourne Research Scholarship. KL is supported by Australian National Health & Medical Research Council (NHMRC) Early Career Fellowship 1091124 and National Heart Foundation Postdoctoral Fellowship 101239. DB is supported by NHMRC Senior Research Fellowship 1064629 and is an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (100369). MW was supported by NHMRC Senior Research Fellowship 1046518, Principal Research Fellowship 1160906 and Cure Kids New Zealand. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program. The funding bodies did not play any role in the study other than the generous provision of funds.