Immunomodulatory effects of renin-angiotensin system inhibitors on T lymphocytes in mice with colorectal liver metastases
Dora Lucia Vallejo Ardila, Katrina A Walsh, Theodora Fifis, Rita Paolini, Georgios Kastrappis, Christopher Christophi, Marcos Vinicius Perini
Journal for ImmunoTherapy of Cancer | BMJ PUBLISHING GROUP | Published : 2020
BACKGROUND: It is now recognized that many anticancer treatments positively modulate the antitumor immune response. Clinical and experimental studies have shown that inhibitors of the classical renin-angiotensin system (RAS) reduce tumor progression and are associated with better outcomes in patients with colorectal cancer. RAS components are expressed by most immune cells and adult hematopoietic cells, thus are potential targets for modulating tumor-infiltrating immune cells and can provide a mechanism of tumor control by the renin-angiotensin system inhibitors (RASi). AIM: To investigate the effects of the RASi captopril on tumor T lymphocyte distribution in a mouse model of colorectal liv..View full abstract
DLVA is supported by the Department of Science, Technology, and Innovation (COLCIENCIAS-Colombia) (PhD overseas 679 program) and the University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences (Postgraduate Research Scholarship 2018-2021). GK was supported by the Australian Rotary Health and Rotary District 9675 Bowelscan PhD Scholarship award. This work was supported by grants from the Austin Medical Research Foundation: (KAW, 2018; MVP, 2018, TF, 2019).