Journal article

Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

RKR Salokangas, J Hietala, RL Armio, H Laurikainen, T From, S Borgwardt, A Riecher-Rossler, P Brambilla, C Bonivento, E Meisenzahl, F Schultze-Lutter, T Haidl, S Ruhrmann, R Upthegrove, SJ Wood, C Pantelis, L Kambeitz-Ilankovic, A Ruef, DB Dwyer, J Kambeitz Show all

SCHIZOPHRENIA RESEARCH | ELSEVIER | Published : 2021

Abstract

BACKGROUND: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. AIM: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. METHOD: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anx..

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Grants

Awarded by European Union


Funding Acknowledgements

PRONIA is a Collaborative Project funded by the European Union under the 7th Framework Programme (grant 602152).The study was funded by Turku University Hospital (EVO funding).