Journal article

Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response

James G Bedford, Giuseppe Infusini, Laura F Dagley, Fernando Villalon-Letelier, Ming ZM Zheng, Vicki Bennett-Wood, Patrick C Reading, Linda M Wakim

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2020

Abstract

Exosomes are extracellular vesicles secreted by cells that have an important biological function in intercellular communication by transferring biologically active proteins, lipids, and RNAs to neighboring or distant cells. While a role for exosomes in antimicrobial defense has recently emerged, currently very little is known regarding the nature and functional relevance of exosomes generated in vivo, particularly during an active viral infection. Here, we characterized exosomes released into the airways during influenza virus infection. We show that these vesicles dynamically change in protein composition over the course of infection, increasing expression of host proteins with known anti-i..

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Grants

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia and the Australian Research Council (LW). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.