Role of adipose tissue in regulating fetal growth in gestational diabetes mellitus
Caitlyn Nguyen-Ngo, Nanthini Jayabalan, Polin Haghvirdizadeh, Carlos Salomon, Martha Lappas
Placenta | W B SAUNDERS CO LTD | Published : 2020
Gestational diabetes mellitus (GDM) is a global health issue with significant short and long-term complications for both mother and baby. There is a strong need to identify an effective therapeutic that can prevent the development of GDM. A better understanding of the pathophysiology of GDM and the relationship between the adipose tissue, the placenta and fetal growth is required. The placenta regulates fetal growth by modulating nutrient transfer of glucose, amino acids and fatty acids. Various factors secreted by the adipose tissue, such as adipokines, adipocytokines and more recently identified extracellular vesicles, can influence inflammation and interact with placental nutrient transpo..View full abstract
Awarded by Fondo Nacional de Desarrollo Cientifico y Tecnologico
The work from M. Lappas's laboratory was funded by grants from National Health and Medical Research Council, Norman Beischer Medical Research Foundation, Diabetes Australia, Austin Medical Research Foundation, Rebecca L. Cooper Foundation, University of Melbourne and ANZ Charitable Trust (Medical Research and Technology Grant). The work from C. Salomon's laboratory was funded by grants from National Health and Medical Research Council, Diabetes Australia and Fondo Nacional de Desarrollo Cientifico y Tecnol.ogico (FONDECYT 1170809).