Conference Proceedings
Can Avoiding So-Called HLA High Risk Epitope Mismatches (REM) Improve Lung Transplant (LTx) Outcomes?
SJ Hiho, MA Paraskeva, DC Walton, MB Diviney, BJ Levvey, GI Snell, LC Sullivan, GP Westall
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation | Published : 2020
Abstract
PURPOSE: HLA epitope mismatches can determine risk of graft rejection and de novo Donor Specific Antibodies (dnDSA) formation. Recently (McCaughan 2018) noted some epitopes posed a greater risk of developing dnDSA post-LTx and assumed this correlated with CLAD and survival. Using these reported REM we aim to determine associations between REM and actual LTx outcomes. METHODS: We retrospectively analysed all 310 primary LTx undertaken Aug 2008-Dec 2015, with both patients and donors' high resolution HLA typed for all HLA loci. Using HLAMatchmaker (v2.1), LTx were assessed for the presence of REM (45GE3 or 45EV/55PP) and DQA1*05. BOS and RAS were determined using the most recent 2019 ISHLT gui..
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