Conference Proceedings

HLA Epitope Mismatch Load (epMM) Allows Classification of Immunological Risk and Correlates with Patient Survival Following Lung Transplantation (LTx)

SJ Hiho, MA Paraskeva, DC Walton, MB Diviney, BJ Levvey, GI Snell, LC Sullivan, GP Westall

The Journal of Heart and Lung Transplantation | Published : 2020

Abstract

PURPOSE: Currently, the assessment of immunological risk in LTx fails to consider HLA compatibility at molecular level, which would allow greater definition of risk of rejection and help clinicians determine best recipients for transplant. The aim of this study was to evaluate HLAMatchmaker epMM in predicting risk of chronic lung allograft rejection (CLAD) and patient survival following LTx. METHODS: We retrospectively analysed all 310 primary LTx undertaken between 01/08/2008-31/12/2015. Recipient and donors were high resolution HLA typed for all HLA loci and HLAMatchmaker (v2.1) used to calculate amino acid differences between them. The epMM was calculated based on the number of epitopes p..

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University of Melbourne Researchers