Evolution of Antimalarial Drug Resistance Markers in the Reservoir of Plasmodium falciparum Infections in the Upper East Region of Ghana
Charles A Narh, Anita Ghansah, Michael F Duffy, Shazia Ruybal-Pesantez, Christiana O Onwona, Abraham R Oduro, Kwadwo A Koram, Karen P Day, Kathryn E Tiedje
The Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020
BACKGROUND: The majority of Plasmodium falciparum infections, constituting the reservoir in all ages, are asymptomatic in high-transmission settings in Africa. The role of this reservoir in the evolution and spread of drug resistance was explored. METHODS: Population genetic analyses of the key drug resistance-mediating polymorphisms were analyzed in a cross-sectional survey of asymptomatic P. falciparum infections across all ages in Bongo District, Ghana. RESULTS: Seven years after the policy change to artemisinin-based combination therapies in 2005, the pfcrt K76 and pfmdr1 N86 wild-type alleles have nearly reached fixation and have expanded via soft selective sweeps on multiple genetic ba..View full abstract
Awarded by Fogarty International Center at the National Institutes of Health, Ecology and Evolution of Infectious Diseases
This work was supported by the Fogarty International Center at the National Institutes of Health, Ecology and Evolution of Infectious Diseases (R01-TW009670 awarded to K. A. K. and K. P. D., salary support to K. E. T.); Australian Government Research Training Program Scholarship (to C. A. N.); The University of Melbourne International Engagement Award (to S. R-P.); The University of Melbourne salary support (to M. F. D. and K. E. T.). The funders had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.