Journal article

Preconceptual paternal environmental stimulation alters behavioural phenotypes and adaptive responses intergenerationally in Swiss mice

Lucas B Hoffmann, Mariana Rae, Priscila Marianno, Terence Y Pang, Anthony J Hannan, Rosana Camarini

Physiology & Behavior | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020

Abstract

Experimental research has recently revealed that paternal environmental conditions can influence the offspring phenotype through epigenetic mechanisms. However, it is unclear whether these effects impact adaptive responses in the offspring. Environmental enrichment (EE) is a well-established paradigm that promotes neural plasticity. We investigated whether EE in male mice could modify behaviours that are highly relevant for determining adaptive fitness, i.e. spatial memory, attractiveness and social dominance, in the offspring of outbred mice. Male Swiss mice were housed in either EE or standard housing from post-weaning to adulthood before breeding for offspring. Their offspring were raised..

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Grants

Awarded by Sao Paulo Research Foundation (FAPESP)


Awarded by Brazilian National Council for Scientific and Technological Development (CNPq)


Awarded by CNPq


Awarded by FAPESP


Funding Acknowledgements

Funding for this study was provided by Sao Paulo Research Foundation (FAPESP, grant #2015/02397-0; 2018/05038-0) and Brazilian National Council for Scientific and Technological Development (CNPq, grant #408228/2016-4) to RC. LH was recipient of scholarships from CNPq (#133994/2016-3), FAPESP (2017/11987-1) and 2018 Endeavour Research Fellowship, the Australian Department of Education and Training and Scope Global. RC is a research fellow of CNPq.