Journal article
Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders
Li-juan Shi, Han-yu Zhou, Yi Wang, Yan-mei Shen, Yu-min Fang, Yu-qiong He, Jian-jun Ou, Hua-bing Li, Xue-rong Luo, Eric FC Cheung, Christos Pantelis, Raymond CK Chan
Asian Journal of Psychiatry | ELSEVIER | Published : 2020
Abstract
Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been reported in both individuals with schizophrenia and autism spectrum disorders (ASD). Despite overlaps, few studies have directly examined the neural mechanisms of impaired empathy in these two clinical groups. We used resting-state fMRI to investigate the neural correlates of empathic functioning in adolescents with ASD (N = 11), early-onset schizophrenia (EOS) (N = 20), and typically developing (TD) controls (N = 26). Their parents completed the Griffith Empathy Measure (GEM) to assess the adolescents' empathic capacity. We found that EOS and ASD participants bot..
View full abstractGrants
Awarded by National Key Research and Development Programme
Awarded by National Natural Science Foundation China
Awarded by China Postdoctoral Science Foundation
Awarded by Humanity and Social Science Youth foundation of the Ministry of Education
Awarded by Natural Science Foundation of Hunan Province
Awarded by Australian NHMRC Senior Principal Research Fellowship
Funding Acknowledgements
This study was supported by the National Key Research and Development Programme (2016YFC0906402), the National Natural Science Foundation China (31970997), the China Postdoctoral Science Foundation (2016M601157), the Humanity and Social Science Youth foundation of the Ministry of Education (17YJC190022), the Natural Science Foundation of Hunan Province (2019JJ50149) and the CAS Key Laboratory of Mental Health, Institute of Psychology. C Pantelis was supported by an Australian NHMRC Senior Principal Research Fellowship (1105825).