Journal article

Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders

Li-juan Shi, Han-yu Zhou, Yi Wang, Yan-mei Shen, Yu-min Fang, Yu-qiong He, Jian-jun Ou, Hua-bing Li, Xue-rong Luo, Eric FC Cheung, Christos Pantelis, Raymond CK Chan

Asian Journal of Psychiatry | ELSEVIER | Published : 2020

Abstract

Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been reported in both individuals with schizophrenia and autism spectrum disorders (ASD). Despite overlaps, few studies have directly examined the neural mechanisms of impaired empathy in these two clinical groups. We used resting-state fMRI to investigate the neural correlates of empathic functioning in adolescents with ASD (N = 11), early-onset schizophrenia (EOS) (N = 20), and typically developing (TD) controls (N = 26). Their parents completed the Griffith Empathy Measure (GEM) to assess the adolescents' empathic capacity. We found that EOS and ASD participants bot..

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University of Melbourne Researchers

Grants

Awarded by National Key Research and Development Programme


Awarded by National Natural Science Foundation China


Awarded by China Postdoctoral Science Foundation


Awarded by Humanity and Social Science Youth foundation of the Ministry of Education


Awarded by Natural Science Foundation of Hunan Province


Awarded by Australian NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

This study was supported by the National Key Research and Development Programme (2016YFC0906402), the National Natural Science Foundation China (31970997), the China Postdoctoral Science Foundation (2016M601157), the Humanity and Social Science Youth foundation of the Ministry of Education (17YJC190022), the Natural Science Foundation of Hunan Province (2019JJ50149) and the CAS Key Laboratory of Mental Health, Institute of Psychology. C Pantelis was supported by an Australian NHMRC Senior Principal Research Fellowship (1105825).