Journal article

The Hippo Pathway as a Driver of Select Human Cancers

Aishwarya Kulkarni, Matthew T Chang, Joseph HA Vissers, Anwesha Dey, Kieran F Harvey

Trends in Cancer | CELL PRESS | Published : 2020


The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Although Hippo has been linked to multiple aspects of cancer, its role in this disease is incompletely understood. Large-scale pan-cancer analyses of core Hippo pathway genes reveal that the pathway is mutated at a high frequency only in select human cancers, including malignant mesothelioma and meningioma. Hippo pathway deregulation is also enriched in squamous epithelial cancers. We discuss cancer-related functions of the Hippo pathway and potential explanations for the cancer-restricted mutation profile of core Hippo pathway genes. Greater understanding of Hippo path..

View full abstract


Funding Acknowledgements

K.F.H. is a National Health and Medical Research Council of Australia Senior Research Fellow (APP1078220). A.K was supported by an Australian Government Research Training Program Scholarship and a Rosie Lew Peter MacCallum Cancer Foundation Postgraduate Award. We apologize to authors whose work we could not cite owing to space limitations.