Journal article

White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype

Anne-Katrin Giese, Markus D Schirmer, Adrian V Dalca, Ramesh Sridharan, Kathleen L Donahue, Marco Nardin, Robert Irie, Elissa C McIntosh, Steven JT Mocking, Huichun Xu, John W Cole, Eva Giralt-Steinhauer, Jordi Jimenez-Conde, Christina Jern, Dawn O Kleindorfer, Robin Lemmens, Johan Wasselius, Arne Lindgren, Tatjana Rundek, Ralph L Sacco Show all

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

OBJECTIVE: To examine etiologic stroke subtypes and vascular risk factor profiles and their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic stroke (AIS). METHODS: For the MRI Genetics Interface Exploration (MRI-GENIE) study, we systematically assembled brain imaging and phenotypic data for 3,301 patients with AIS. All cases underwent standardized web tool-based stroke subtyping with the Causative Classification of Ischemic Stroke (CCS). WMH volume (WMHv) was measured on T2 brain MRI scans of 2,529 patients with a fully automated deep-learning trained algorithm. Univariable and multivariable linear mixed-effects modeling was carried out to..

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Grants

Awarded by NIH-National Institutes of Neurological Disorders and Stroke


Awarded by NIH National Institute of Biomedical Imaging and Bioengineering


Awarded by ISGS


Awarded by Instituto de Salud Carlos III


Awarded by Fondos FEDER/EDRF Red de Investigacion Cardiovascular


Awarded by Fundacio la Marato TV3


Awarded by Recercaixa'13


Awarded by European Union


Funding Acknowledgements

Funding provided by NIH-National Institutes of Neurological Disorders and Stroke (MRI-GENIE: R01NS086905-principal investigator N. Rost; K23NS064052, R01NS082285-N. Rost; SiGN: U01 NS069208-J. Rosand, S. Kittner; R01NS059775, R01NS063925, R01NS082285, P50NS051343, R01NS086905, U01NS069208-O. Wu), NIH National Institute of Biomedical Imaging and Bioengineering (P41EB015902-P. Golland, U01NS030678-B. Kissela, D. Kleindorfer; EB015325-O. Wu), ISGS: R01NS423733-principal investigator J. Meschia, Swedish Heart and Lung Foundation, Lund University, Region Skane, the Freemasons Lodge of Instruction Eos Lund, Skane University Hospital, the Foundation of Fars&Frosta-one of Sparbanken Skane's ownership foundations, and the Swedish Stroke Association-A. Lindgren, Swedish Research Council and the Swedish Heart and Lung Foundation, the Swedish State under the ALF agreement-C. Jern, Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (Funding for Research in Health [PI051737], [PI10/02064], [PI12/01238], and [PI15/00451-J. Jimenez-Conde]), Fondos FEDER/EDRF Red de Investigacion Cardiovascular (RD12/0042/0020-J. Jimenez-Conde), Fundacio la Marato TV3 (76/C/2011-J. Jimenez-Conde) and Recercaixa'13 (JJ086116-J. Jimenez-Conde), and Wistron Corp (P. Golland). This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 753896 (M.D. Schirmer). R.L. is a senior clinical investigator of FWO Flanders.