A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy
Samira Imran, Melanie R Neeland, Rebecca Shepherd, Nicole Messina, Kirsten P Perrett, Mihai G Netea, Nigel Curtis, Richard Saffery, Boris Novakovic
iScience | CELL PRESS | Published : 2020
The prevalence of IgE-mediated food allergy is increasing at a rapid pace in many countries. The association of high food allergy rates with Westernized lifestyles suggests the role of gene-environment interactions, potentially underpinned by epigenetic variation, in mediating this process. Recent studies have implicated innate immune system dysfunction in the development and persistence of food allergy. These responses are characterized by increased circulating frequency of innate immune cells and heightened inflammatory responses to bacterial stimulation in food allergic patients. These signatures mirror those described in trained immunity, whereby innate immune cells retain a "memory" of ..View full abstract
Awarded by NHMRC
RS is supported by an NHMRC Project Grant (1165073); BN is supported by an NHMRC Project Grant (1157556) and anNHMRC Investigator Grant (1173314). MNis supported by an MCRI Lifecourse Fellowship. KPP is supported by a Melbourne Children's Clinician Scientist Fellowship. MGN is supported by an ERC Advanced Grant and a Spinoza grant from the Netherlands Organisation for Scientific Research (NWO). Figures were adapted from Servier Medical Art.