Journal article

Spectrum of cerebral arteriopathies in children with arterial ischemic stroke

Mubeen F Rafay, Kevin A Shapiro, Ann-Marie Surmava, Gabrielle A deVber, Adam Kirton, Heather J Fullerton, Catherine Amlie-Lefond, Bernhard Weschke, Nomazulu Dlamini, Jessica L Carpenter, Mark T Mackay, Michael Rivkin, Alexandra Linds, Timothy J Bernard

NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

OBJECTIVE: To determine that children with arterial ischemic stroke (AIS) due to an identifiable arteriopathy are distinct from those without arteriopathy and that each arteriopathy subtype has unique and recognizable clinical features. METHODS: We report a large, observational, multicenter cohort of children with AIS, age 1 month to 18 years, enrolled in the International Pediatric Stroke Study from 2003 to 2014. Clinical and demographic differences were compared by use of the Fisher exact test, with linear step-up permutation min-p adjustment for multiple comparisons. Exploratory analyses were conducted to evaluate differences between cases of AIS with and without arteriopathy and between ..

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Grants

Awarded by Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (HHS)


Awarded by NIH


Awarded by European Community's Seventh Framework Program (FP7/2007-2013)


Funding Acknowledgements

Mubeen F. Rafay is supported by a research operating grant from the Children Hospital Research Institute of Manitoba. Dr. Timothy J. Bernard is supported by the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (HHS) under grant 2H30MC24049, Mountain States Hemophilia Network. This information or content and conclusions are those of the author and should not be construed as the official position or policy of, nor should any endorsements be inferred by, HRSA, HHS, or the US government. Dr. Gabrielle deVeber and Dr. Heather J. Fullerton are supported by NIH R01 NS062820. Dr. Bernhard Weschke has received funding from the European Community's Seventh Framework Program (FP7/2007-2013) under grant 602391 (epistop.eu). The IPSS is graciously supported by The Auxilium Foundation.