Journal article

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan

Cancers | MDPI | Published : 2020

Abstract

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection with hepatitis B virus (HBV) is a major risk factor for liver cancer, as is deregulated Wnt signaling, however, the interaction between these two causes is poorly understood. To investigate this interaction, we screened the effect of the various HBV proteins for their effect on Wnt/β-catenin signaling and identified the pre-core protein p22 as a novel and potent activator of TCF/β-catenin transcription. The effect of p22 on TCF/β-catenin transcription was dose dependent and inhibited by dominant-negative TCF4. HBV p22 activated synthetic and native Wnt target gene p..

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Grants

Awarded by Melbourne Health


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by MRC


Funding Acknowledgements

This research was funded by Melbourne Health through a project grant number PG-002-2016 awarded to E.V.; T.J.P.; G.E.; N.W.; T.F.; and C.C.; and a post-graduate scholarship to B.M.T.; E.V.; and T.J.P. were funded, in part, by grants from the National Health and Medical Research Council (NHMRC), project grant number APP1099302 and investigator grant number APP1181580. T.J.P. was funded by BLS/CMU Fellowship and MRC (MR/R026424/1). D.J.F.; was funded, in part, by a Cancer Council of Victoria fellowship and a Melbourne Health early career grant GIA-033-2016.