Whole-Cell Pertussis Vaccination and Decreased Risk of IgE-Mediated Food Allergy: A Nested Case-Control Study
Marie J Estcourt, Dianne E Campbell, Michael S Gold, Peter Richmond, Katrina J Allen, Helen E Quinn, Julie A Marsh, Rachel L Peters, Carolina Valerio, Danyi Dai, Claire S Waddington, Nicholas J Wood, Peter B McIntyre, Patrick G Holt, Thomas L Snelling
The Journal of Allergy and Clinical Immunology: In Practice | ELSEVIER | Published : 2020
BACKGROUND: Rates of food allergy have increased markedly in Australia and other high- income countries in recent years. On the basis of ecological observations, and the known immunologic characteristics of whole-cell pertussis (wP) compared with acellular pertussis (aP) vaccines, we hypothesized that wP vaccination in infancy protects against the development of food allergy. OBJECTIVE: To determine whether infants who receive wP in infancy were less likely to develop IgE-mediated food allergy than those who received aP. METHODS: Retrospective cohort-nested case-control study of Australian children born in the period 1997 to 1999, the period of transition from using wP-containing to aP-conta..View full abstract
Awarded by NHMRC Project Grant
Awarded by NHMRC Career Development Fellowship
This research was funded by the National Health and Medical Research Council (NHMRC) of Australia (https://www.nhmrc.gov.au/funding).The NHMRC Project Grant (grant no. APP1069772) was awarded to T.L.S., D.E.C., M.S.G., P.R., K.J.A., H.E.Q., C.S.W., N.J.W., P.B.M., and P.G.H. T.L.S. is supported by an NHMRC Career Development Fellowship (GNT1111657). The funder of the study approved the study design, but had no role in the collection, analysis, and interpretation of data, or in the writing of the report or the decision to submit it for publication.