Journal article

Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA

Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley Show all

NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address this heterogeneity with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power. We conducted random-effects meta-analyses, mixed-effects mega-analyses and ComBat mega-analyses to compare cortic..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Awarded by National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF)


Awarded by NIH


Awarded by NSF


Awarded by Medical Research Council of South Africa


Awarded by Ministry of Health, Czech Republic -Conceptual Development of Research Organization


Awarded by NPU


Awarded by Catalan Government


Awarded by European Union (ERDF/ESF, 'Investing in your future')


Awarded by German Research Foundation (DFG)


Awarded by Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster


Awarded by German Ministry for Education and Research (BMBF; Brain Imaging Center Frankfurt/Main)


Awarded by National Natural Science Foundation of China


Awarded by Beijing Municipal Science and Technology Commission grant


Awarded by Beijing Natural Science Foundation


Awarded by Beijing Municipal Administration of Hospitals Clinical medicine Development


Awarded by Australian National Health and Medical Research Council of Australia (NHMRC)


Awarded by Macquarie University's Australian Research Council Centre of Excellence in Cognition and its Disorders


Awarded by National Institutes of Health


Awarded by Madrid Regional Government


Awarded by State of Maryland


Awarded by Oxford study MRC


Awarded by Italian Ministry of Health


Awarded by RFBR


Awarded by Swiss National Science Foundation


Awarded by National Healthcare Group, Singapore


Awarded by Singapore Bioimaging Consortium


Awarded by Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning


Awarded by National Institutes of Mental Health


Awarded by National Center for Advancing Translational Sciences, National Institutes of Health


Awarded by Dutch Organization for Health Research and Development


Awarded by National Institute of Mental Health


Awarded by ENIGMA's NIH Big Data to Knowledge (BD2K) initiative


Awarded by ENIGMA Sex Differences


Awarded by ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits



Funding Acknowledgements

ASRB: The Australian Schizophrenia Research Bank (ASRB) was supported by the National Health and Medical Research Council of Australia (NHMRC) (Enabling Grant, ID 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute. Chief Investigators for ASRB were Carr, V., Schall, U., Scott, R., Jablensky, A., Mowry, B., Michie, P., Catts, S., Henskens, F., Pantelis, C. We thank Loughland, C., the ASRB Manager, and acknowledge the help of Jason Bridge for ASRB database queries. CP was supported by NHMRC Senior Principal Research Fellowships (IDs: 628386 & 1105825); GC was supported by the Schizophrenia Research Institute utilizing infrastructure funding from the New South Wales Ministry of Health and New South Wales Ministry of Trade and Investment (Australia); JMF was supported by NHMRC project grant (1063960) and the Janette Mary O'Neil Research Fellowship; MJG was supported by NHMRC as an R.D. Wright Biomedical Career Development Fellow (1061875). MJC was supported by NHMRC Senior Research Fellowship (1121474).CASSI: CSW is funded by the NSW Ministry of Health, Office of Health and Medical Research. CSW is a recipient of a National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF) (#1117079).CIAM: The CIAM study (FMH -PI) was supported by the University Research Committee, University of Cape Town and South African funding bodies National Research Foundation and Medical Research Council.COBRE: The COBRE dataset and investigators were supported by NIH grants R01EB006841 & P20GM103472, as well as NSF grant 1539067. JT (senior author) and VDC are supported by 5R01MH094524. JMS is supported by R01 AA021771 and P50 AA022534.EONCKS: This work was supported by a New Partnership for Africa's Development (NEPAD) grant through the Department of Science and Technology of South Africa, the Medical Research Council of South Africa (grant number 65174).ESO: The ESO study was funded by NPU I -LO1611 and Ministry of Health, Czech Republic -Conceptual Development of Research Organization 00023001 (IKEM).FIDMAG/Project: This work was supported by the Catalan Government (2017-SGR-1271, 2017-SGR-1365, SLT002/16/00331 and SLT006/17/00357) and several grants from the Instituto de Salud Carlos III and co-funded by European Union (ERDF/ESF, 'Investing in your future'): Miguel Servet Research Contracts (CPII19/00009 to JR, CPII13/00018 to RS and CPII16/00018 to EP-C) and Research Project Grants (PI14/01151, PI14/01148, PI14/00292, PI15/00277, PI15/00283 and PI19/00394).FOR2107 Marburg: The FOR2107 Marburg study was funded by the German Research Foundation (DFG), Tilo Kircher (speaker FOR2107; DFG grant numbers KI 588/14-1, KI 588/14-2), Axel Krug (KR 3822/5-1, KR 3822/7-2), Igor Nenadic (NE 2254/1-2), Carsten Konrad (KO 4291/3-1).FOR2107 Muenster: The FOR2107 Muenster study was funded by the German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to UD) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant Dan3/012/17 to UD). TH was supported by grants from the German Research Foundation (DFG grants HA7070/2-2, HA7070/3, HA7070/4).Frankfurt: MRI was performed at the Frankfurt Brain Imaging Center, supported by the German Research Council (DFG) and the German Ministry for Education and Research (BMBF; Brain Imaging Center Frankfurt/Main, DLR 01GO0203).GIPSI: This study was supported by Colciencias PRISMA-U.T.Huilong1 & Huilong2: This study was funded by the National Natural Science Foundation of China (81761128021; 31671145; 81401115; 81401133), Beijing Municipal Science and Technology Commission grant (Z141107002514016) and Beijing Natural Science Foundation(7162087, Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding (XMLX201609; zylx201409).IGP: This study was funded by Project Grants from the Australian National Health and Medical Research Council of Australia (NHMRC; APP630471 and APP1081603), the Macquarie University's Australian Research Council Centre of Excellence in Cognition and its Disorders (CE110001021).Johns Hopkins: Supported by National Institutes of Health Grant Nos. MH-092443, MH-094268 (Silvio O. Conte Center), MH-105660, and MH107730; foundation grants from Stanley, RUSK/S-R, and NARSAD/Brain and Behavior Research Foundation.Madrid: Supported by the Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III, co-financed by ERDF Funds from the European Commission, "A way of making Europe", CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds and European Union Seventh Framework Program and H2020 Program; Fundacion Familia Alonso, Fundacion Alicia Koplowitz and Fundacion Mutua Madrilena.MPRC1 & MPRC2: Support was received from NIH grants U01MH108148, 2R01EB015611, R01MH112180, R01DA027680, R01MH085646, P50MH103222 and T32MH067533, a State of Maryland contract (M00B6400091) and NSF grant (1620457).OLIN: The Olin study was supported by NIH grants R37MH43375 and R01MH074797.Oxford: The Oxford study MRC G0500092.SLF Rome: Support from the Italian Ministry of Health grants RC-1213-14-15-16-17-18-19/A.RSCZ: RSCZ data collection was supported by RFBR 15-06-05758 grant.SCORE: This study was supported in part by grant 3232BO_119382 from the Swiss National Science Foundation. We thank the FePsy (Frueherkennung von Psychosen; early detection of psychosis) Study Group from the University of Basel, Department of Psychiatry, Switzerland, for the recruitment of the study participants. The FePsy Study was supported in part by grant No. SNF 3200-057216/1, ext./2,ext./3.Singapore: This study was supported by research grants from the National Healthcare Group, Singapore (SIG/05004; SIG/11003), and the Singapore Bioimaging Consortium (RP C-009/2006) research grants awarded to KS.SNUH: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (Grant no. 2013R1A2A1A03071089 and 2017M3C7A1029610).UCISZ: The UCISZ study was supported by the National Institutes of Mental Health grant number R21MH097196 to TGMvE. UCISZ data were processed by the UCI High Performance Computing cluster supported by Joseph Farran, Harry Mangalam, and Adam Brenner and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1 TR000153.UNIBA: The UNIBA study was supported by grant funding from the Italian Ministry of Health (PE-2011-02347951).UNIMAAS: The study was supported by Dutch Organization for Health Research and Development (ZonMw 91112002) and a personal grant to Therese van Amelsvoort (ZonMw-VIDI: 91712394). The data was collected in a clinical trial registered in the Dutch clinical trial registry under ID: NTR5094 (http://www.trialregister.nl).UPenn: This study was supported by the National Institute of Mental Health grants MH064045, MH 60722, MH019112, MH085096 (DHW), and R01MH112847 (RTS and TDS).Research reported in this publication was also supported by the following National Institutes of Health grants: U54 EB020403 to PMT, R01 MH116147, U24 RR21992, R21MH097196, and TR000153 to TGMvE, S10 OD023696 and R01EB015611 to PK, T32 AG058507and 5T32 MH073526 to CRKC, R01 MH117601 to NJ, ENIGMA's NIH Big Data to Knowledge (BD2K) initiative U54 EB020403, ENIGMA Sex Differences R01MH116147, and ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits R01MH121246.