Journal article

The human gut microbiota and depression: widely reviewed, yet poorly understood

Carra A Simpson, Orli S Schwartz, Julian G Simmons

Journal of Affective Disorders | ELSEVIER | Published : 2020

Abstract

BACKGROUND: A large number of existing reviews have discussed the role of the gut microbiota in affective disorders, though syntheses have been overwhelmingly narrative in their focus. METHOD: In this correspondence, we compliment Sanada et al. (2020) on their recent systematic review of the gut microbiota in Major Depressive Disorder (MDD), the first to incorporate a meta-analysis. We also comment on how this synthesis should be extended in future research. RESULTS: Sanada et al. (2020) conducted a meta-analysis of alpha diversity in participants with MDD compared to controls, whereby they unexpectedly observed no significant difference between groups. A meta-analysis was only able to be pe..

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