Journal article

The multi-faceted mechano-bactericidal mechanism of nanostructured surfaces

Elena P Ivanova, Denver P Linklater, Marco Werner, Vladimir A Baulin, XiuMei Xu, Nandi Vrancken, Sergey Rubanov, Eric Hanssen, Jason Wandiyanto, Vi Khanh Truong, Aaron Elbourne, Shane Maclaughlin, Saulius Juodkazis, Russell J Crawford

Proceedings of the National Academy of Sciences of the United States of America | National Academy of Sciences | Published : 2020

Abstract

The mechano-bactericidal activity of nanostructured surfaces has become the focus of intensive research toward the development of a new generation of antibacterial surfaces, particularly in the current era of emerging antibiotic resistance. This work demonstrates the effects of an incremental increase of nanopillar height on nanostructure-induced bacterial cell death. We propose that the mechanical lysis of bacterial cells can be influenced by the degree of elasticity and clustering of highly ordered silicon nanopillar arrays. Herein, silicon nanopillar arrays with diameter 35 nm, periodicity 90 nm and increasing heights of 220, 360, and 420 nm were fabricated using deep UV immersion lithogr..

View full abstract

Grants

Awarded by Australian Research Council (ARC) Industrial Transformation Research Hubs Scheme


Awarded by ARC Industrial Transformation Training Centre (ITTC) scheme


Funding Acknowledgements

We acknowledge the facilities as well as scientific and technical assistance of the Australian Microscopy & Microanalysis Research Facility at the RMIT University Microscopy & Microanalysis Facility. We thank the Bio21 Advanced Microscopy Facility (The University of Melbourne) for the use of their FEI Nova SEM. N.V. acknowledges the Fonds Voor Wetenschappelijk Onderzoek for a research grant. Funding from the Australian Research Council (ARC) Industrial Transformation Research Hubs Scheme (Project IH130100017) and ARC Industrial Transformation Training Centre (ITTC) scheme (Project IC180100005) to E.P.I. are gratefully acknowledged.