Journal article
Prevalence, incidence, and natural history of HPV infection in adult women ages 24 to 45 participating in a vaccine trial
DG Ferris, DR Brown, AR Giuliano, E Myers, EA Joura, SM Garland, SK Kjaer, G Perez, A Saah, A Luxembourg, C Velicer
Papillomavirus Research | ELSEVIER | Published : 2020
Open access
Abstract
Objectives: The natural history of human papillomavirus (HPV) infection has been studied extensively in young women; this study investigated HPV infection in adult women. Methods: Data from 3817 women aged 24–45 years in a global trial of the 4-valent HPV (6/11/16/18) vaccine were used to calculate prevalence of anogenital infections containing 9-valent (9v) HPV vaccine types (6/11/16/18/31/33/45/52/58) and five non-vaccine types (35/39/51/56/59). Incidence of infections and persistent infections was estimated for 989 placebo recipients naive to all 14 HPV types at baseline. Age-adjusted hazard ratios were calculated for various sociodemographic factors. Results: Prevalence of anogenital inf..
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Funding Acknowledgements
Funding for this research was provided by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. This study was designed, managed, and analyzed jointly by authors employed by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. and external authors who were not paid for their work. Medical writing assistance was provided by ApotheCom (New York, NY, USA) and was funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.