Journal article

Quantitative MRI as an imaging marker of concussion: evidence from studying repeated events

M Pedersen, M Makdissi, DM Parker, T Barbour, DF Abbott, P McCrory, GD Jackson



We present a 23-year-old male professional Australian Football player who experienced a total of seven sports-related concussions between May-2015-March-2019, not associated with loss of consciousness (see supplementary materials for clinical details). Advanced brain imaging was performed after the latter four of these, revealing that his brain underwent a pattern of focal, but transient, increases in T2 relaxometry following concussive events.


Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

The authors wish to thank the AFL Doctors Association, the AFL Players Association, Dr Patrick Clifton (AFL Operations and Innovations Manager) and Dr Peter Harcourt (AFL Medical Director) for their support of the project. We also thank all the recruited subjects who gave their valuable time to participate in this study. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. We also acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility, an Australian Government National Collaborative Research Infrastructure Strategy capability, at the Florey node, and the Victorian Biomedical Imaging Capability. This study was supported in part by the National Health and Medical Research Council of Australia, grant number #1060312 (GJ Practitioner Fellowship) and #1026383 (PM Practitioner Fellowship). D.A. is supported by fellowship funding from the National Imaging Facility. Funding for the MRI scans was provided by the AFL.