Journal article
Continuous Magnesium Infusion to Prevent Atrial Fibrillation After Cardiac Surgery: A Sequential Matched Case-Controlled Pilot Study
EA Osawa, SL Cutuli, L Cioccari, L Bitker, L Peck, H Young, L Hessels, F Yanase, JT Fukushima, LA Hajjar, S Seevanayagam, G Matalanis, GM Eastwood, R Bellomo
Journal of Cardiothoracic and Vascular Anesthesia | W B SAUNDERS CO-ELSEVIER INC | Published : 2020
Abstract
Objective: The authors aimed to test whether a bolus of magnesium followed by continuous intravenous infusion might prevent the development of atrial fibrillation (AF) after cardiac surgery. Design: Sequential, matched, case-controlled pilot study. Setting: Tertiary university hospital. Participants: Matched cohort of 99 patients before and intervention cohort of 99 consecutive patients after the introduction of a continuous magnesium infusion protocol. Interventions: The magnesium infusion protocol consisted of a 10 mmol loading dose of magnesium sulphate followed by a continuous infusion of 3 mmol/h over a maximum duration of 96 hours or until intensive care unit discharge. Measurements an..
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Funding Acknowledgements
Financial support for this study was received from the Anesthesia and Intensive Care Trust Fund, Austin Hospital. The funding source had no involvement in study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the article for publication.