Continuous Magnesium Infusion to Prevent Atrial Fibrillation After Cardiac Surgery: A Sequential Matched Case-Controlled Pilot Study
Eduardo A Osawa, Salvatore L Cutuli, Luca Cioccari, Laurent Bitker, Leah Peck, Helen Young, Lara Hessels, Fumitaka Yanase, Julia T Fukushima, Ludhmila A Hajjar, Siven Seevanayagam, George Matalanis, Glenn M Eastwood, Rinaldo Bellomo
Journal of Cardiothoracic and Vascular Anesthesia | W B SAUNDERS CO-ELSEVIER INC | Published : 2020
OBJECTIVE: The authors aimed to test whether a bolus of magnesium followed by continuous intravenous infusion might prevent the development of atrial fibrillation (AF) after cardiac surgery. DESIGN: Sequential, matched, case-controlled pilot study. SETTING: Tertiary university hospital. PARTICIPANTS: Matched cohort of 99 patients before and intervention cohort of 99 consecutive patients after the introduction of a continuous magnesium infusion protocol. INTERVENTIONS: The magnesium infusion protocol consisted of a 10 mmol loading dose of magnesium sulphate followed by a continuous infusion of 3 mmol/h over a maximum duration of 96 hours or until intensive care unit discharge. MEASUREMENTS AN..View full abstract
Financial support for this study was received from the Anesthesia and Intensive Care Trust Fund, Austin Hospital. The funding source had no involvement in study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the article for publication.