Journal article

Continuous Magnesium Infusion to Prevent Atrial Fibrillation After Cardiac Surgery: A Sequential Matched Case-Controlled Pilot Study

Eduardo A Osawa, Salvatore L Cutuli, Luca Cioccari, Laurent Bitker, Leah Peck, Helen Young, Lara Hessels, Fumitaka Yanase, Julia T Fukushima, Ludhmila A Hajjar, Siven Seevanayagam, George Matalanis, Glenn M Eastwood, Rinaldo Bellomo

Journal of Cardiothoracic and Vascular Anesthesia | W B SAUNDERS CO-ELSEVIER INC | Published : 2020

Abstract

OBJECTIVE: The authors aimed to test whether a bolus of magnesium followed by continuous intravenous infusion might prevent the development of atrial fibrillation (AF) after cardiac surgery. DESIGN: Sequential, matched, case-controlled pilot study. SETTING: Tertiary university hospital. PARTICIPANTS: Matched cohort of 99 patients before and intervention cohort of 99 consecutive patients after the introduction of a continuous magnesium infusion protocol. INTERVENTIONS: The magnesium infusion protocol consisted of a 10 mmol loading dose of magnesium sulphate followed by a continuous infusion of 3 mmol/h over a maximum duration of 96 hours or until intensive care unit discharge. MEASUREMENTS AN..

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Grants

Funding Acknowledgements

Financial support for this study was received from the Anesthesia and Intensive Care Trust Fund, Austin Hospital. The funding source had no involvement in study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the article for publication.