Journal article

Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the life course: The Cardiovascular Risk in Young Finns Study

Marie-Jeanne Buscot, Feitong Wu, Markus Juonala, Terho Lehtimaki, Niina Pitkanen, Matthew A Sabin, Jorma SA Viikari, Olli T Raitakari, Costan G Magnussen

International Journal of Obesity | NATURE PUBLISHING GROUP | Published : 2020

Abstract

BACKGROUND: The role of genetic risk scores associated with adult body mass index (BMI) on BMI levels across the life course is unclear. We examined if a 97 single nucleotide polymorphism weighted genetic risk score (wGRS97) associated with age-related progression in BMI at different life stages and distinct developmental trajectories of BMI across the early life course. METHODS: 2188 Cardiovascular Risk in Young Finns Study participants born pre-1980 who had genotype data and objective measurements of height and weight collected up to 8 times from age 6 to 49 years. Associations were examined using Individual Growth Curve analysis, Latent Class Growth Mixture Modelling, and Poisson modified..

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Grants

Awarded by Academy of Finland


Awarded by Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals


Awarded by EU Horizon 2020


Awarded by European Research Council


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

The YFS has been financially supported by the Academy of Finland: grants 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; and EU Horizon 2020 (grant 755320 for TAXINOMISIS); and European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation. CGM is supported by National Heart Foundation of Australia Future Leader Fellowship (100849).