Hyperosmotic Infusion and Oxidized Surfaces Are Essential for Biofilm Formation of Staphylococcus capitis From the Neonatal Intensive Care Unit.
Yue Qu, Yali Li, David R Cameron, Christopher D Easton, Xuebo Zhu, Minli Zhu, Mario Salwiczek, Benjamin W Muir, Helmut Thissen, Andrew Daley, John S Forsythe, Anton Y Peleg, Trevor Lithgow
Frontiers in Microbiology | Published : 2020
Staphylococcus capitis is an opportunistic pathogen often implicated in bloodstream infections in the neonatal intensive care unit (NICU). This is assisted by its ability to form biofilms on indwelling central venous catheters (CVC), which are highly resistant to antibiotics and the immune system. We sought to understand the fundamentals of biofilm formation by S. capitis in the NICU, using seventeen clinical isolates including the endemic NRCS-A clone and assessing nine commercial and two modified polystyrene surfaces. S. capitis clinical isolates from the NICU initiated biofilm formation only in response to hyperosmotic conditions, followed by a developmental progression driven by icaADBC ..View full abstract