Environmental enrichment modulates affiliative and aggressive social behaviour in the neuroligin-3 R451C mouse model of autism spectrum disorder
EL Burrows, L Koyama, C May, EL Hill-Yardin, AJ Hannan
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by impairments in social communication and the presence of restrictive and repetitive behaviours. A mouse model expressing an autism-associated R451C mutation in the gene encoding the synaptic adhesion protein neuroligin-3 (NL3) has been extensively characterised and shows altered behaviour relevant to core traits observed in ASD. Reported impairments in social behaviours in NL3R451C mice however remain controversial due to inconsistent findings in various assays across different laboratories. Such inconsistencies could plausibly be explained by an increased susceptibility of the NL3R451C mouse social phenotype to ..View full abstract
Awarded by National Health and Medical Research Council-Australian Research Council (NHMRC-ARC) Dementia Research Development Fellowship
Awarded by ARC Future Fellowship
Awarded by Australian Research Council (ARC) FT3 Future Fellowship
ELB is supported by a National Health and Medical Research Council-Australian Research Council (NHMRC-ARC) Dementia Research Development Fellowship (1111552). EH-Y is supported by an ARC Future Fellowship (ARC FT 160100126) and an RMIT Vice Chancellor's Senior Research Fellowship. AJH has been supported by an Australian Research Council (ARC) FT3 Future Fellowship (FT100100835) and is currently supported by an NHMRC Principal Research Fellowship and NHMRC Project Grants.