Journal article

Sex-specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: TheADVANCE-ONstudy

Toshiaki Ohkuma, Sanne AE Peters, Min Jun, Stephen Harrap, Mark Cooper, Pavel Hamet, Neil Poulter, John Chalmers, Mark Woodward

Diabetes, Obesity and Metabolism | WILEY | Published : 2020

Abstract

AIM: To examine possible sex differences in the excess risk of myocardial infarction (MI) consequent to a range of conventional risk factors in a large-scale international cohort of patients with diabetes, and to quantify these potential differences both on the relative and absolute scales. MATERIALS AND METHODS: Eleven thousand and sixty-five participants (42% women) with type 2 diabetes in the ADVANCE trial and its post-trial follow-up study, ADVANCE-ON, were included. Cox regression models were used to estimate hazard ratios (HRs) for associations between risk factors and MI (fatal and non-fatal) by sex, and the women-to-men ratio of HRs (RHR). RESULTS: Over a median of 9.6 years of follo..

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