Journal article

Targeting Wnt Signaling for the Treatment of Gastric Cancer

Sarah Koushyar, Arfon G Powell, Elizabeth Vincan, Toby J Phesse

International Journal of Molecular Sciences | MDPI | Published : 2020


The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeostasis. Wnt signaling controls several fundamental cell functions, including proliferation, differentiation, migration, and stemness. It therefore plays an important role in the epithelial homeostasis and regeneration of the gastrointestinal tract. Often, both hypo- or hyper-activation of the pathway due to genetic, epigenetic, or receptor/ligand alterations are seen in many solid cancers, such as breast, colorectal, gastric, and prostate. Gastric cancer (GC) is the fourth commonest cause of cancer worldwide and is the second leading cause of cancer-related death ann..

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Awarded by Medical Research Council

Awarded by AMMF Cholangiocarcinoma Charity

Awarded by Royal College of Surgeons England

Awarded by National Health and Medical Research Council, Australia

Funding Acknowledgements

Funding is gratefully acknowledged from the following: Medical Research Council (MR/R026424/1 to TJP), AMMF Cholangiocarcinoma Charity (2019/201 to TJP) and Royal College of Surgeons England (PO112607 to AP) Cardiff University/CMU Research Fellowship (to TJP); National Health and Medical Research Council, Australia (APP1099302 and APP1181580 to EV and TJP).