Journal article

Plasma cytokine profiles in very preterm infants with late-onset sepsis

Julie Hibbert, Tobias Strunk, Karen Simmer, Peter Richmond, David Burgner, Andrew Currie

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

INTRODUCTION: Deficiencies in innate immune responses may contribute to the increased susceptibility to infection in preterm infants. In vivo cytokine profiles in response to sepsis in very preterm infants are not fully understood. AIMS: To characterise plasma pro- and anti-inflammatory cytokine concentrations and pre-defined ratios in very preterm infants with late-onset sepsis (LOS). METHODS: In this observational study, peripheral blood samples were collected at the time of evaluation for suspected LOS from 31 preterm infants (<30 weeks gestational age). Plasma cytokine concentrations were determined by 12-plex immunoassay. RESULTS: IL-10, IFN-γ, IL-12p70, IP-10, IL-6 and CCL2 were elevat..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (572548, www.nhmrc.gov.au).TS is supported by a Raine Medical Research Foundation Clinician Research Fellowship (rainefoundation.org.au). DB is supported by NHMRC Research Fellowship (www.nhmrc.gov.au).JH is supported by a University Postgraduate Award (www.education.gov.au).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.